NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection

NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection

Summary: Genital herpes is characterized by recurrent episodes of epithelial blistering. The mechanisms causing this pathology are ill defined. Using a mouse model of vaginal herpes simplex virus 2 (HSV-2) infection, we show that interleukin-18 (IL-18) acts upon natural killer (NK) cells to promote...

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Bibliographic Details
Main Authors: Ying Shiang Lim, Aisha G. Lee, Xiaoping Jiang, Jason M. Scott, Adjoa Cofie, Sandeep Kumar, Dania Kennedy, David J. Granville, Haina Shin
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Cell Reports
Subjects:
CP: Immunology
Biological Sciences
Immunology and Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723004217

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http://www.sciencedirect.com/science/article/pii/S2211124723004217

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