Codon usage bias regulates gene expression and protein conformation in yeast expression system P. pastoris

Codon usage bias regulates gene expression and protein conformation in yeast expression system P. pastoris

Abstract Background Protein synthesis is one of the extremely important anabolic pathways in the yeast expression system Pichia pastoris. Codon optimization is a commonly adopted strategy for improved protein expression, although unexpected failures did appear sometimes waiting for further explorati...

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Bibliographic Details
Main Authors: Yichun Xu, Kunshan Liu, Yu Han, Yanzi Xing, Yuanxing Zhang, Qiuying Yang, Mian Zhou
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Microbial Cell Factories
Subjects:
Codon bias
P. pastoris
Protein expression
Conformation
Online Access:https://doi.org/10.1186/s12934-021-01580-9

Internet

https://doi.org/10.1186/s12934-021-01580-9

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