Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia

Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia

Abstract Hereditary spastic paraplegias (HSPs) are a group of inherited, progressive neurodegenerative conditions characterised by prominent lower-limb spasticity and weakness, caused by a length-dependent degeneration of the longest corticospinal upper motor neurons. While more than 80 spastic para...

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Bibliographic Details
Main Authors: Dwayne J. Byrne, M. Elena Garcia-Pardo, Nelson B. Cole, Belguun Batnasan, Sophia Heneghan, Anood Sohail, Craig Blackstone, Niamh C. O’Sullivan
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Acta Neuropathologica Communications
Subjects:
Neurodegeneration
Endoplasmic reticulum
Lipid droplet
Drosophila model
Online Access:https://doi.org/10.1186/s40478-022-01343-6

Internet

https://doi.org/10.1186/s40478-022-01343-6

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