Estimating Allele Frequency from Next-Generation Sequencing of Pooled Mitochondrial DNA Samples

Estimating Allele Frequency from Next-Generation Sequencing of Pooled Mitochondrial DNA Samples

Background: Both common and rare mitochondrial DNA (mtDNA) variants may contribute to genetic susceptibility to some complex human diseases. Next-generation sequencing of pooled mtDNA samples may represent an cost-effective approach for large-scale genetic epidemiology studies. However, the performa...

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Bibliographic Details
Main Authors: Tao eWang, Kith ePradhan, Kenny eYe, Lee-jun eWong, Thomas E Rohan
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-08-01
Series:Frontiers in Genetics
Subjects:
Allele frequency
next generation sequencing
mitochondria DNA
pooled sequencing
sequencing error
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2011.00051/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2011.00051/full

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