Estimating Allele Frequency from Next-Generation Sequencing of Pooled Mitochondrial DNA Samples
Background: Both common and rare mitochondrial DNA (mtDNA) variants may contribute to genetic susceptibility to some complex human diseases. Next-generation sequencing of pooled mtDNA samples may represent an cost-effective approach for large-scale genetic epidemiology studies. However, the performa...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2011-08-01
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Series: | Frontiers in Genetics |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2011.00051/full |