Fibrosis in atrial fibrillation – role of reactive species and MPO

Fibrosis in atrial fibrillation – role of reactive species and MPO

Atrial fibrosis with enhanced turnover and deposition of matrix proteins leads to inhomogeneous atrial electrical conduction and gives rise to electrical reentry circuits resulting in atrial fibrillation. The multifactorial pathogenesis of atrial fibrosis involves resident cardiac cells as well as i...

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Bibliographic Details
Main Authors: Kai eFriedrichs, Stephan eBaldus, Anna eKlinke
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Physiology
Subjects:
Atrial Fibrillation
Fibrosis
Reactive Oxygen Species
Myeloperoxidase
matrix metalloproteinase
myofibroblast
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00214/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00214/full

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