Glycosylation of CaV3.2 Channels Contributes to the Hyperalgesia in Peripheral Neuropathy of Type 1 Diabetes

Glycosylation of CaV3.2 Channels Contributes to the Hyperalgesia in Peripheral Neuropathy of Type 1 Diabetes

Our previous studies implicated glycosylation of the CaV3.2 isoform of T-type Ca2+ channels (T-channels) in the development of Type 2 painful peripheral diabetic neuropathy (PDN). Here we investigated biophysical mechanisms underlying the modulation of recombinant CaV3.2 channel by de-glycosylation...

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Bibliographic Details
Main Authors: Sonja Lj. Joksimovic, J. Grayson Evans, William E. McIntire, Peihan Orestes, Paula Q. Barrett, Vesna Jevtovic-Todorovic, Slobodan M. Todorovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
dorsal root ganglion
T-type calcium channel
neuropathic pain
sensitization
excitability
low-voltage-activated
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.605312/full

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https://www.frontiersin.org/articles/10.3389/fncel.2020.605312/full

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