Ryanodine receptor RyR1-mediated elevation of Ca2+ concentration is required for the late stage of myogenic differentiation and fusion

Ryanodine receptor RyR1-mediated elevation of Ca2+ concentration is required for the late stage of myogenic differentiation and fusion

Abstract Background Cytosolic Ca2+ plays vital roles in myogenesis and muscle development. As a major Ca2+ release channel of endoplasmic reticulum (ER), ryanodine receptor 1 (RyR1) key mutations are main causes of severe congenital myopathies. The role of RyR1 in myogenic differentiation has attrac...

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Bibliographic Details
Main Authors: Kai Qiu, Yubo Wang, Doudou Xu, Linjuan He, Xin Zhang, Enfa Yan, Lu Wang, Jingdong Yin
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Journal of Animal Science and Biotechnology
Subjects:
Apoptosis
Ca2+ homeostasis
Endoplasmic reticulum stress
Myoblast fusion
Myogenic differentiation
RyR1 knockout
Online Access:https://doi.org/10.1186/s40104-021-00668-x

Internet

https://doi.org/10.1186/s40104-021-00668-x

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