Lipidomic approach for stratification of acute myeloid leukemia patients.
The pathogenesis and progression of many tumors, including hematologic malignancies is highly dependent on enhanced lipogenesis. De novo fatty-acid synthesis permits accelerated proliferation of tumor cells by providing membrane components but these may also alter physicochemical properties of lipid...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5313223?pdf=render |
| _version_ | 1819100407516889088 |
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| author | Adam Stefanko Christian Thiede Gerhard Ehninger Kai Simons Michal Grzybek |
| author_facet | Adam Stefanko Christian Thiede Gerhard Ehninger Kai Simons Michal Grzybek |
| author_sort | Adam Stefanko |
| collection | DOAJ |
| description | The pathogenesis and progression of many tumors, including hematologic malignancies is highly dependent on enhanced lipogenesis. De novo fatty-acid synthesis permits accelerated proliferation of tumor cells by providing membrane components but these may also alter physicochemical properties of lipid bilayers, which can impact signaling or even increase drug resistance in cancer cells. Cancer type-specific lipid profiles would permit us to monitor and interpret actual effects of lipid changes, potential fingerprints of individual tumors to be explored as diagnostic markers. We have used the shotgun MS approach to identify lipid patterns in different types of acute myeloid leukemia (AML) patients that either show no karyotype change or belong to t(8;21) or inv16 types. Differences in lipidomes of t(8;21) and inv(16) patients, as compared to AML patients without karyotype change, presented mostly as substantial modulation of ceramide/sphingolipid synthesis. Furthermore, between the t(8;21) and all other patients we observed significant changes in physicochemical membrane properties. These were related to a marked alteration in lipid saturation levels. The discovered differences in lipid profiles of various AML types improve our understanding of the pathobiochemical pathways involved and may serve in the development of diagnostic tools. |
| first_indexed | 2024-12-22T01:02:17Z |
| format | Article |
| id | doaj.art-9ccf48640a8c47dea3b9cd8b51b0306d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T01:02:17Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9ccf48640a8c47dea3b9cd8b51b0306d2022-12-21T18:44:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e016878110.1371/journal.pone.0168781Lipidomic approach for stratification of acute myeloid leukemia patients.Adam StefankoChristian ThiedeGerhard EhningerKai SimonsMichal GrzybekThe pathogenesis and progression of many tumors, including hematologic malignancies is highly dependent on enhanced lipogenesis. De novo fatty-acid synthesis permits accelerated proliferation of tumor cells by providing membrane components but these may also alter physicochemical properties of lipid bilayers, which can impact signaling or even increase drug resistance in cancer cells. Cancer type-specific lipid profiles would permit us to monitor and interpret actual effects of lipid changes, potential fingerprints of individual tumors to be explored as diagnostic markers. We have used the shotgun MS approach to identify lipid patterns in different types of acute myeloid leukemia (AML) patients that either show no karyotype change or belong to t(8;21) or inv16 types. Differences in lipidomes of t(8;21) and inv(16) patients, as compared to AML patients without karyotype change, presented mostly as substantial modulation of ceramide/sphingolipid synthesis. Furthermore, between the t(8;21) and all other patients we observed significant changes in physicochemical membrane properties. These were related to a marked alteration in lipid saturation levels. The discovered differences in lipid profiles of various AML types improve our understanding of the pathobiochemical pathways involved and may serve in the development of diagnostic tools.http://europepmc.org/articles/PMC5313223?pdf=render |
| spellingShingle | Adam Stefanko Christian Thiede Gerhard Ehninger Kai Simons Michal Grzybek Lipidomic approach for stratification of acute myeloid leukemia patients. PLoS ONE |
| title | Lipidomic approach for stratification of acute myeloid leukemia patients. |
| title_full | Lipidomic approach for stratification of acute myeloid leukemia patients. |
| title_fullStr | Lipidomic approach for stratification of acute myeloid leukemia patients. |
| title_full_unstemmed | Lipidomic approach for stratification of acute myeloid leukemia patients. |
| title_short | Lipidomic approach for stratification of acute myeloid leukemia patients. |
| title_sort | lipidomic approach for stratification of acute myeloid leukemia patients |
| url | http://europepmc.org/articles/PMC5313223?pdf=render |
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