NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis.

NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis.

Maintenance of healthy bone requires the balanced activities of osteoclasts (OCs), which resorb bone, and osteoblasts, which build bone. Disproportionate action of OCs is responsible for the bone loss associated with postmenopausal osteoporosis and rheumatoid arthritis. NF-κB inducing kinase (NIK) c...

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Bibliographic Details
Main Authors: Chang Yang, Kathleen McCoy, Jennifer L Davis, Marc Schmidt-Supprian, Yoshiteru Sasaki, Roberta Faccio, Deborah Veis Novack
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2975662?pdf=render

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http://europepmc.org/articles/PMC2975662?pdf=render

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