The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells.
The EWS-ERG fusion protein is found in human sarcomas with the chromosomal translocation t(21;22)(q22;q12), where the translocation is considered to be an initiating event in sarcoma formation within uncommitted mesenchymal cells, probably long-lived progenitors capable of self renewal. The fusion p...
| Format: | Article |
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| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-08-01
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| Series: | PLoS Biology |
| Online Access: | http://dx.doi.org/10.1371/journal.pbio.0030242 |