Stage-dependent prognostic shift in mismatch repair-deficient tumors: Assessing patient outcomes in stage II and III colon cancer

Stage-dependent prognostic shift in mismatch repair-deficient tumors: Assessing patient outcomes in stage II and III colon cancer

IntroductionDeficient mismatch repair (dMMR) or high microsatellite instability (MSI-H) is associated with an improved prognosis in colon cancer stage II but poor prognosis in stage IV colon cancer. The clinical significance of dMMR in colon cancer stage III is not established.MethodsTissue microarr...

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Bibliographic Details
Main Authors: Kjersti Elvestad Hestetun, Nina Benedikte Rosenlund, Luka Stanisavljević, Olav Dahl, Mette Pernille Myklebust
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
microsatellite instability
mismatch repair (MMR)
colon cancer
prognosis
stage
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.853545/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.853545/full

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