Enhanced protein synthesis is a defining requirement for neonatal B cell development

Enhanced protein synthesis is a defining requirement for neonatal B cell development

The LIN28B RNA binding protein exhibits an ontogenically restricted expression pattern and is a key molecular regulator of fetal and neonatal B lymphopoiesis. It enhances the positive selection of CD5+ immature B cells early in life through amplifying the CD19/PI3K/c-MYC pathway and is sufficient to...

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Bibliographic Details
Main Authors: Hugo Åkerstrand, Elena Boldrin, Giorgia Montano, Stijn Vanhee, Karin Olsson, Niklas Krausse, Stefano Vergani, Maciej Cieśla, Cristian Bellodi, Joan Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
LIN28B
protein synthesis
B-1 cells
neonatal B cell development
c-MYC
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1130930/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1130930/full

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