Neurodegeneration in Niemann–Pick Type C Disease: An Updated Review on Pharmacological and Non-Pharmacological Approaches to Counteract Brain and Cognitive Impairment

Neurodegeneration in Niemann–Pick Type C Disease: An Updated Review on Pharmacological and Non-Pharmacological Approaches to Counteract Brain and Cognitive Impairment

Niemann–Pick type C (NPC) disease is an autosomal recessive storage disorder, characterized by abnormal sequestration of unesterified cholesterol in the late endo-lysosomal system of cells. Progressive neurological deterioration and the onset of symptoms, such as ataxia, seizures, cognitive decline,...

Full description

Bibliographic Details
Main Authors: Ida Cariati, Laura Masuelli, Roberto Bei, Virginia Tancredi, Claudio Frank, Giovanna D’Arcangelo
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
Niemann–Pick type C
neurodegeneration
cognitive decline
lipid trafficking
pharmacological treatment
physical exercise
Online Access:https://www.mdpi.com/1422-0067/22/12/6600

Internet

https://www.mdpi.com/1422-0067/22/12/6600

Similar Items