Myeloid Protease-Activated Receptor-2 Contributes to Influenza A Virus Pathology in Mice

Myeloid Protease-Activated Receptor-2 Contributes to Influenza A Virus Pathology in Mice

BackgroundInnate immune responses to influenza A virus (IAV) infection are initiated in part by toll-like receptor 3 (TLR3). TLR3-dependent signaling induces an antiviral immune response and an NFκB-dependent inflammatory response. Protease-activated receptor 2 (PAR2) inhibits the antiviral response...

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Bibliographic Details
Main Authors: Randall C. Gunther, Vanthana Bharathi, Stephen D. Miles, Lauryn R. Tumey, Clare M. Schmedes, Kohei Tatsumi, Meagan D. Bridges, David Martinez, Stephanie A. Montgomery, Melinda A. Beck, Eric Camerer, Nigel Mackman, Silvio Antoniak
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
toll-like receptor 3
influenza A virus
innate immune response
macrophage
lung epithelial cell
protease-activated receptor 2 (PAR2)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.791017/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.791017/full

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