Ischemic accumulation of succinate induces Cdc42 succinylation and inhibits neural stem cell proliferation after cerebral ischemia/reperfusion

Ischemic accumulation of succinate induces Cdc42 succinylation and inhibits neural stem cell proliferation after cerebral ischemia/reperfusion

Ischemic accumulation of succinate causes cerebral damage by excess production of reactive oxygen species. However, it is unknown whether ischemic accumulation of succinate affects neural stem cell proliferation. In this study, we established a rat model of cerebral ischemia/reperfusion injury by oc...

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Bibliographic Details
Main Authors: Lin-Yan Huang, Ju-Yun Ma, Jin-Xiu Song, Jing-Jing Xu, Rui Hong, Hai-Di Fan, Heng Cai, Wan Wang, Yan-Ling Wang, Zhao-Li Hu, Jian-Gang Shen, Su-Hua Qi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Neural Regeneration Research
Subjects:
cdc42; cerebral ischemia/reperfusion injury; gpr91; neural stem cells; neurogenesis; proliferation; sirt5; succinate; succinylation
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=5;spage=1040;epage=1045;aulast=Huang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=5;spage=1040;epage=1045;aulast=Huang

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