The intracellular seven amino acid motif EEGEVFL is required for matriptase vesicle sorting and translocation to the basolateral plasma membrane.

The intracellular seven amino acid motif EEGEVFL is required for matriptase vesicle sorting and translocation to the basolateral plasma membrane.

Matriptase plays important roles in epithelial integrity and function, which depend on its sorting to the basolateral surface of cells, where matriptase zymogen is converted to an active enzyme in order to act on its substrates. After activation, matriptase undergoes HAI-1-mediated inhibition, inter...

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Bibliographic Details
Main Authors: Chun-Che Tseng, Bailing Jia, Robert B Barndt, Yang-Hong Dai, Yu Hsin Chen, Po-Wen A Du, Jehng-Kang Wang, Hung-Jen Tang, Chen-Yong Lin, Michael D Johnson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0228874

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https://doi.org/10.1371/journal.pone.0228874

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