Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer’s disease mouse model and proteomics analysis

Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer’s disease mouse model and proteomics analysis

The pathophysiology of Alzheimer’s disease (AD) is multifactorial with characteristic extracellular accumulation of amyloid-beta (Aβ) and intraneuronal aggregation of hyperphosphorylated tau in the brain. Development of disease-modifying treatment for AD has been challenging. Recent studies suggest...

Full description

Bibliographic Details
Main Authors: Xinhua Zhou, Kaipeng Huang, Yuqiang Wang, Zaijun Zhang, Yingying Liu, Qinghua Hou, Xifei Yang, Maggie Pui Man Hoi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
alhzheimer disease
tetramethylpyrazine nitrone
amyloid beta
proteomic analysis
PINK1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1082602/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1082602/full

Similar Items