Ca2+-dependent endoplasmic reticulum stress correlation with astrogliosis involves upregulation of KCa3.1 and inhibition of AKT/mTOR signaling

Ca2+-dependent endoplasmic reticulum stress correlation with astrogliosis involves upregulation of KCa3.1 and inhibition of AKT/mTOR signaling

Abstract Background The intermediate-conductance Ca2+-activated K+ channel KCa3.1 was recently shown to control the phenotype switch of reactive astrogliosis (RA) in Alzheimer’s disease (AD). Methods KCa3.1 channels expression and cell localization in the brains of AD patients and APP/PS1 mice model...

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Bibliographic Details
Main Authors: Zhihua Yu, Fangfang Dou, Yanxia Wang, Lina Hou, Hongzhuan Chen
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Endoplasmic reticulum stress
Mouse model
Unfolded protein response
KCa3.1
Online Access:http://link.springer.com/article/10.1186/s12974-018-1351-x

Internet

http://link.springer.com/article/10.1186/s12974-018-1351-x

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