The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

Abstract Background The R47H variant of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) confers greatly increased risk for Alzheimer’s disease (AD), reflective of a central role for myeloid cells in neurodegeneration. Understanding how this variant confers AD risk promises to provide import...

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Bibliographic Details
Main Authors: Paul J. Cheng-Hathaway, Erin G. Reed-Geaghan, Taylor R. Jay, Brad T. Casali, Shane M. Bemiller, Shweta S. Puntambekar, Victoria E. von Saucken, Roxanne Y. Williams, J. Colleen Karlo, Miguel Moutinho, Guixiang Xu, Richard M. Ransohoff, Bruce T. Lamb, Gary E. Landreth
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Molecular Neurodegeneration
Subjects:
TREM2
Neuroinflammation
Innate immunity
CRISPR/Cas9
Single nucleotide polymorphism
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s13024-018-0262-8

Internet

http://link.springer.com/article/10.1186/s13024-018-0262-8

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