In-silico and in-vitro analysis of novel substituted benzimidazolyl derivatives for antimycobacterial potentials targeting enoyl acyl carrier protein reductase (InhA)

In-silico and in-vitro analysis of novel substituted benzimidazolyl derivatives for antimycobacterial potentials targeting enoyl acyl carrier protein reductase (InhA)

Abstract Background The emergence of mutated drug-resistant strains of Mycobacterium tuberculosis has reinvigorated the development of effective chemotherapy for MDR-TB (multidrug-resistant resistance tuberculosis). Enoyl acyl carrier protein reductase (InhA) involved in the mycobacterial fatty acid...

Full description

Bibliographic Details
Main Authors: Umaa Kuppuswamy, Ravi Kumar Rajan, Arvinth Kumar, Muthiah Ramanathan
Format: Article
Language:English
Published: SpringerOpen 2022-12-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Substituted benzimidazoles
Docking
Molecular dynamics
Synthesis
Characterization
Antimycobacterial screening
Online Access:https://doi.org/10.1186/s43094-022-00449-x

Internet

https://doi.org/10.1186/s43094-022-00449-x

Similar Items