Class II transactivator induces expression of MHC-I and MHC-II in transmissible Tasmanian devil facial tumours

Class II transactivator induces expression of MHC-I and MHC-II in transmissible Tasmanian devil facial tumours

MHC-I and MHC-II molecules are critical components of antigen presentation and T cell immunity to pathogens and cancer. The two monoclonal transmissible devil facial tumours (DFT1, DFT2) exploit MHC-I pathways to overcome immunological anti-tumour and allogeneic barriers. This exploitation underpins...

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Bibliographic Details
Main Authors: Chrissie E. B. Ong, Yuanyuan Cheng, Hannah V. Siddle, A. Bruce Lyons, Gregory M. Woods, Andrew S. Flies
Format: Article
Language:English
Published: The Royal Society 2022-10-01
Series:Open Biology
Subjects:
transmissible cancer
devil facial tumour
DFTD
MHC
CIITA
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.220208

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.220208

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