Canine Intestinal Organoids as a Novel In Vitro Model of Intestinal Drug Permeability: A Proof-of-Concept Study

Canine Intestinal Organoids as a Novel In Vitro Model of Intestinal Drug Permeability: A Proof-of-Concept Study

A key component of efforts to identify the biological and drug-specific aspects contributing to therapeutic failure or unexpected exposure-associated toxicity is the study of drug–intestinal barrier interactions. While methods supporting such assessments are widely described for human therapeutics,...

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Bibliographic Details
Main Authors: Dipak Kumar Sahoo, Marilyn N. Martinez, Kimberly Dao, Vojtech Gabriel, Christopher Zdyrski, Albert E. Jergens, Todd Atherly, Chelsea A. Iennarella-Servantez, Laura E. Burns, Dwayne Schrunk, Donna A. Volpe, Karin Allenspach, Jonathan P. Mochel
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
canine
3D organoid
permeability
Caco-2
colon
Online Access:https://www.mdpi.com/2073-4409/12/9/1269

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https://www.mdpi.com/2073-4409/12/9/1269

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