Macrophage-organoid co-culture model for identifying treatment strategies against macrophage-related gemcitabine resistance

Macrophage-organoid co-culture model for identifying treatment strategies against macrophage-related gemcitabine resistance

Abstract Background Gemcitabine resistance (GR) is a significant clinical challenge in pancreatic adenocarcinoma (PAAD) treatment. Macrophages in the tumor immune-microenvironment are closely related to GR. Uncovering the macrophage-induced GR mechanism could help devise a novel strategy to improve...

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Bibliographic Details
Main Authors: Shengwei Jiang, Tingwei Deng, Huan Cheng, Weihan Liu, Dan Shi, Jiahui Yuan, Zhiwei He, Weiwei Wang, Boning Chen, Li Ma, Xianbin Zhang, Peng Gong
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Gemcitabine resistance
Organoids
Macrophages
Cancer stem cells
Online Access:https://doi.org/10.1186/s13046-023-02756-4

Internet

https://doi.org/10.1186/s13046-023-02756-4

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