Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination

Inflammatory diseases: Putting on the brakes Acetate, a short-chain fatty acid, reduces activation of the NLRP3 inflammasome, a multiprotein complex that mediates inflammation. Acetate is produced by gut bacteria and can stimulate the synthesis of fat. High levels of acetate have been associated wit...

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Bibliographic Details
Main Authors: Mengda Xu, Zhengyu Jiang, Changli Wang, Na Li, Lulong Bo, Yanping Zha, Jinjun Bian, Yan Zhang, Xiaoming Deng
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-019-0276-5