Rhodopsin targeted transcriptional silencing by DNA-binding

Rhodopsin targeted transcriptional silencing by DNA-binding

Transcription factors (TFs) operate by the combined activity of their DNA-binding domains (DBDs) and effector domains (EDs) enabling the coordination of gene expression on a genomic scale. Here we show that in vivo delivery of an engineered DNA-binding protein uncoupled from the repressor domain can...

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Bibliographic Details
Main Authors: Salvatore Botta, Elena Marrocco, Nicola de Prisco, Fabiola Curion, Mario Renda, Martina Sofia, Mariangela Lupo, Annamaria Carissimo, Maria Laura Bacci, Carlo Gesualdo, Settimio Rossi, Francesca Simonelli, Enrico Maria Surace
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
AAV
rhodopsin
transcription
gene expression
gene therapy
neurodegeneration
Online Access:https://elifesciences.org/articles/12242

Internet

https://elifesciences.org/articles/12242

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