Soluble CX3CL1-expressing retinal pigment epithelium cells protect rod photoreceptors in a mouse model of retinitis pigmentosa

Soluble CX3CL1-expressing retinal pigment epithelium cells protect rod photoreceptors in a mouse model of retinitis pigmentosa

Abstract Background Retinitis pigmentosa (RP) is an inherited retinal disease that results in photoreceptor degeneration, leading to severe vision loss or blindness. Due to its genetic heterogeneity, developing a new gene therapy to correct every genetic mutation contributing to its progression is i...

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Bibliographic Details
Main Authors: Eric D. Jong, Sabiha Hacibekiroglu, Lily Guo, Evan Sawula, Biao Li, Chengjin Li, Margaret T. Ho, Molly S. Shoichet, Valerie A. Wallace, Andras Nagy
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Stem Cell Research & Therapy
Subjects:
Retinal degeneration
Retinitis pigmentosa
Cell therapy
Gene therapy
Microglia activation
Online Access:https://doi.org/10.1186/s13287-023-03434-0

Internet

https://doi.org/10.1186/s13287-023-03434-0

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