Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression

Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression

An in vitro model of human ovarian follicles would greatly benefit the study of female reproduction. Ovarian development requires the combination of germ cells and several types of somatic cells. Among these, granulosa cells play a key role in follicle formation and support for oogenesis. Whereas ef...

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Bibliographic Details
Main Authors: Merrick D Pierson Smela, Christian C Kramme, Patrick RJ Fortuna, Jessica L Adams, Rui Su, Edward Dong, Mutsumi Kobayashi, Garyk Brixi, Venkata Srikar Kavirayuni, Emma Tysinger, Richie E Kohman, Toshi Shioda, Pranam Chatterjee, George M Church
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-02-01
Series:eLife
Subjects:
granulosa
oogenesis
transcription factors
stem cells
ovary
Online Access:https://elifesciences.org/articles/83291

Internet

https://elifesciences.org/articles/83291

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