Gold Compounds Inhibit the Ca<sup>2+</sup>-ATPase Activity of Brain PMCA and Human Neuroblastoma SH-SY5Y Cells and Decrease Cell Viability

Gold Compounds Inhibit the Ca<sup>2+</sup>-ATPase Activity of Brain PMCA and Human Neuroblastoma SH-SY5Y Cells and Decrease Cell Viability

Plasma membrane calcium ATPases (PMCA) are key proteins in the maintenance of calcium (Ca<sup>2+</sup>) homeostasis. Dysregulation of PMCA function is associated with several human pathologies, including neurodegenerative diseases, and, therefore, these proteins are potential drug target...

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Bibliographic Details
Main Authors: Maria Berrocal, Juan J. Cordoba-Granados, Sónia A. C. Carabineiro, Carlos Gutierrez-Merino, Manuel Aureliano, Ana M. Mata
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Metals
Subjects:
gold compounds
PMCA
Ca<sup>2+</sup>-ATPase
calcium homeostasis
SH-SY5Y human neuroblastoma cells
Online Access:https://www.mdpi.com/2075-4701/11/12/1934

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https://www.mdpi.com/2075-4701/11/12/1934

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