Transcriptomic signatures induced by the Ebola virus vaccine rVSVΔG-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study

Transcriptomic signatures induced by the Ebola virus vaccine rVSVΔG-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study

Summary: Background: A recombinant vesicular stomatitis virus vector expressing the Zaire Ebola virus glycoprotein (rVSVΔG-ZEBOV-GP) vaccine has been reported as safe, immunogenic, and highly protective in a ring vaccination trial. We aimed to identify transcriptomic immune response biomarker signa...

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Main Authors: Eleonora Vianello, PhD, Patricia Gonzalez-Dias, MSc, Suzanne van Veen, BSc, Carmen G Engele, BSc, Edwin Quinten, BSc, Thomas P Monath, MD, Donata Medaglini, ProfPhD, Francesco Santoro, PhD, Angela Huttner, MD, Sheri Dubey, PhD, Michael Eichberg, PhD, Francis M Ndungu, PhD, Peter G Kremsner, ProfMD, Paulin N Essone, PhD, Selidji Todagbe Agnandji, MD, Claire-Anne Siegrist, ProfMD, Helder I Nakaya, PhD, Tom H M Ottenhoff, ProfMD, Mariëlle C Haks, PhD, Selidij T Agnandij, Rafi Ahmed, Jenna Anderson, Floriane Auderset, Philip Bejon, Luisa Borgianni, Jessica Brosnahan, Annalisa Ciabattini, Olivier Engler, Mariëlle C Haks, Ali M Harandi, Donald G Heppner, Alice Gerlini, Angela Huttner, Peter G Kremsner, Donata Medaglini, Thomas P Monath, Francis M Ndungu, Patricia Njuguna, Tom H M Ottenhoff, David Pejoski, Mark Page, Gianni Pozzi, Francesco Santoro, Claire-Anne Siegrist, Sheri Dubey, Michael Eichberg, Essone P Ndong, Kabwende Lumeka, Helder I Nakaya, Patricia Gonzales Dias Carvalho, Sylvia Rothenberger, Eleonora Vianello, Sravya S Nakka, Suzanne van Veen
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:The Lancet Microbe
Online Access:http://www.sciencedirect.com/science/article/pii/S2666524721002354

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http://www.sciencedirect.com/science/article/pii/S2666524721002354

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