Pan-cancer analysis of AIM2 inflammasomes with potential implications for immunotherapy in human cancer: A bulk omics research and single cell sequencing validation

Pan-cancer analysis of AIM2 inflammasomes with potential implications for immunotherapy in human cancer: A bulk omics research and single cell sequencing validation

BackgroundThe absent in melanoma 2 (AIM2) inflammasome is a multi-protein platform that recognizes aberrant cytoplasmic double-stranded DNA(dsDNA) and induces cytokine maturation, release, and pyroptosis. Some studies found that the AIM2 inflammasome was a double-edged sword in many cancers. However...

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Bibliographic Details
Main Authors: Yan Qin, Liuxian Pan, Tianyu Qin, Hanyi Ruan, Yujie Zhang, Yan Zhang, Jianli Li, Jianrong Yang, Wei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
AIM2 inflammasomes
single-cell transcriptome sequencing
pan-cancer
immunotherapy
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.998266/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.998266/full

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