Primitive Erythropoiesis in the Mouse is Independent of DOT1L Methyltransferase Activity

Primitive Erythropoiesis in the Mouse is Independent of DOT1L Methyltransferase Activity

DOT1-like (DOT1L) histone methyltransferase is essential for mammalian erythropoiesis. Loss of DOT1L in knockout (Dot1l-KO) mouse embryos resulted in lethal anemia at midgestational age. The only recognized molecular function of DOT1L is its methylation of histone H3 lysine 79 (H3K79). We generated...

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Bibliographic Details
Main Authors: Carrie A. Malcom, Anamika Ratri, Joanna Piasecka-Srader, Shaon Borosha, V. Praveen Chakravarthi, Nehemiah S. Alvarez, Jay L. Vivian, Timothy A. Fields, M.A. Karim Rumi, Patrick E. Fields
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
DOT1L methyltransferase
Dot1l methyltransferase mutant mouse
erythroid progenitor
erythroid differentiation
early blood development
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.813503/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.813503/full

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