Role of Neural (N)-Cadherin in Breast Cancer Cell Stemness and Dormancy in the Bone Microenvironment

Role of Neural (N)-Cadherin in Breast Cancer Cell Stemness and Dormancy in the Bone Microenvironment

Breast cancer cells that interact with spindle-shaped N-Cadherin<sup>+</sup> Osteoblasts (SNOs) are recognised to become dormant through a Notch2-dependent mechanism. We found that Notch2<sup>High</sup> human BrCa MDA-MB231 (MDA) cells also expressed high level of N-Cadherin....

Full description

Bibliographic Details
Main Authors: Antonio Maurizi, Michela Ciocca, Cristiano Giuliani, Ilaria Di Carlo, Anna Teti
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
BrCa dormancy
cancer stem cells
HSC-mimicry
osteoblasts
endosteal niche
bone microenvironment
Online Access:https://www.mdpi.com/2072-6694/14/5/1317

Internet

https://www.mdpi.com/2072-6694/14/5/1317

Similar Items