Ursolic acid induces apoptosis and pyroptosis in Reh cells by upregulating of the JNK signalling pathway based on network pharmacology and experimental validation

Ursolic acid induces apoptosis and pyroptosis in Reh cells by upregulating of the JNK signalling pathway based on network pharmacology and experimental validation

Objective: To explore the mechanism of ursolic acid (UA) against acute B lymphoblastic leukaemia (B-ALL) based on network pharmacological analysis, molecular docking and experimental verification. Methods: The core targets, functional processes, and biological pathways of UA in B-ALL were predicted...

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Bibliographic Details
Main Authors: Ying Luo, Jing Xiang, Shuangyang Tang, Shiting Huang, Yishan Zhou, Haiyan Shen
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Heliyon
Subjects:
Ursolic acid
Acute B lymphoblastic leukaemia
Apoptosis
Pyroptosis
JNK
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023102878

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http://www.sciencedirect.com/science/article/pii/S2405844023102878

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