Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37

Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37

The effect of the anti-inflammatory cytokine interleukin-37 (IL 37) on host defense against Candida infections remains unknown. We assessed the role of IL 37 in a murine model of disseminated candidiasis using mice transgenic for human IL 37 (hIL 37Tg). Upon exposure to C. albicans pseudohyphae, m...

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Bibliographic Details
Main Authors: Frank L. Van De Veerdonk, Mark S Gresnigt, Jos WM Van Der Meer, Leo eJoosten, Mihai eNetea, Charles eDinarello
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Microbiology
Subjects:
Candida
Neutrophils
TNFa
IL-37
antifungal host defense
IL-1F7
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00762/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00762/full

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