Rapid Downregulation of H3K4me3 Binding to Immunoregulatory Genes in Altered Gravity in Primary Human M1 Macrophages

Rapid Downregulation of H3K4me3 Binding to Immunoregulatory Genes in Altered Gravity in Primary Human M1 Macrophages

The sensitivity of human immune system cells to gravity changes has been investigated in numerous studies. Human macrophages mediate innate and thus rapid immune defense on the one hand and activate T- and B-cell-based adaptive immune response on the other hand. In this process they finally act as i...

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Bibliographic Details
Main Authors: Christian Vahlensieck, Cora Sandra Thiel, Swantje Christoffel, Sabrina Herbst, Jennifer Polzer, Beatrice Astrid Lauber, Saskia Wolter, Liliana Elisabeth Layer, Jochen Hinkelbein, Svantje Tauber, Oliver Ullrich
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
microgravity
immune system
epigenetics
parabolic flight
ChIP-seq
formaldehyde fixation
Online Access:https://www.mdpi.com/1422-0067/24/1/603

Internet

https://www.mdpi.com/1422-0067/24/1/603

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