NCF4 regulates antigen presentation of cysteine peptides by intracellular oxidative response and restricts activation of autoreactive and arthritogenic T cells

Autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematous, are regulated by polymorphisms in genes contributing to the NOX2 complex. Mutations in both Ncf1 and Ncf4 affect development of arthritis in experimental models of RA, but the different regulatory pathways mediat...

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Bibliographic Details
Main Authors:	Jing Xu, Chang He, Yongsong Cai, Xipeng Wang, Jidong Yan, Jing Zhang, Fujun Zhang, Vilma Urbonaviciute, Yuanyuan Cheng, Shemin Lu, Rikard Holmdahl
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Series:	Redox Biology
Subjects:	Neutrophil cytosolic factor 4 (NCF4, earlier often denoted p40phox) Neutrophil cytosolic factor 1 (NCF1, earlier often denoted p47phox) Intracellular reactive oxygen species Redox regulation Antigen presentation T cell activation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231724001083

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http://www.sciencedirect.com/science/article/pii/S2213231724001083

NCF4 regulates antigen presentation of cysteine peptides by intracellular oxidative response and restricts activation of autoreactive and arthritogenic T cells

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