Lipid Dys-Homeostasis Contributes to APOE4-Associated AD Pathology

Lipid Dys-Homeostasis Contributes to APOE4-Associated AD Pathology

The association of the APOE4 (vs. APOE3) isoform with an increased risk of Alzheimer’s disease (AD) is unequivocal, but the underlying mechanisms remain incompletely elucidated. A prevailing hypothesis incriminates the impaired ability of APOE4 to clear neurotoxic amyloid-β peptides (Aβ) from the br...

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Bibliographic Details
Main Authors: Adina-Nicoleta Lazar, Linda Hanbouch, Lydie Boussicaut, Baptiste Fourmaux, Patricia Daira, Mark J. Millan, Nathalie Bernoud-Hubac, Marie-Claude Potier
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
lipid homeostasis
APOE4
Alzheimer’s disease
Aβ peptide
tau
Online Access:https://www.mdpi.com/2073-4409/11/22/3616

Internet

https://www.mdpi.com/2073-4409/11/22/3616

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