Characterization of Three Novel IMP Metallo-β-Lactamases, IMP-89, IMP-91, and IMP-96, and Diverse blaIMP-Carrying Accessory Genetic Elements from Chinese Clinical Isolates

Characterization of Three Novel IMP Metallo-β-Lactamases, IMP-89, IMP-91, and IMP-96, and Diverse blaIMP-Carrying Accessory Genetic Elements from Chinese Clinical Isolates

ABSTRACT Three novel imipenemase (IMP)-type metallo-β-lactamases (MBLs), referred to as IMP-89, IMP-91, and IMP-96, were detected in three clinical isolates from China. Antimicrobial susceptibility tests indicated these novel enzymes were resistant to most β-lactams, and IMP-96 with a Ser262Gly muta...

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Bibliographic Details
Main Authors: Xinyue Li, Xiaofei Mu, Fangzhou Chen, Xiuhui Lu, Jiaqi He, Yali Zheng, Dongsheng Zhou, Zhe Yin, Peng Wang
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
antimicrobial resistance
IMP-type MBLs
accessory genetic elements
genome sequencing
comparative genomic analysis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04986-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.04986-22

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