Implementation of QbD Approach to the Analytical Method Development and Validation for the Estimation of Metformin Hydrochloride in Tablet Dosage Forms by HPLC

Implementation of QbD Approach to the Analytical Method Development and Validation for the Estimation of Metformin Hydrochloride in Tablet Dosage Forms by HPLC

The current studies entail quality by design (QbD)-enabled development of a simple, rapid, precise, accurate, and cost-effective high-performance liquid chromatographic method for estimation of metformin hydrochloride (M-HCl). Design of experiments (DoE) was applied for multivariate optimization of...

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Bibliographic Details
Main Authors: Mousa Sha’at, Adrian Florin Spac, Iulian Stoleriu, Alexandra Bujor, Monica Stamate Cretan, Mihaela Hartan, Lacramioara Ochiuz
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceutics
Subjects:
metformin hydrochloride
quality by design (QbD)
central composite design (CCD)
critical analytical attributes (CAA)
HPLC
validation
Online Access:https://www.mdpi.com/1999-4923/14/6/1187

Internet

https://www.mdpi.com/1999-4923/14/6/1187

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