Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer

Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer

Abstract Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer in the adult population. Late diagnosis, resistance to therapeutics and recurrence of metastatic lesions account for the highest mortality rate among kidney cancer patients. Identifying novel biomarkers for early cance...

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Bibliographic Details
Main Authors: Laura Rinaldi, Francesco Chiuso, Emanuela Senatore, Domenica Borzacchiello, Luca Lignitto, Rosa Iannucci, Rossella Delle Donne, Mariano Fuggi, Carla Reale, Filomena Russo, Nicola Antonino Russo, Giorgio Giurato, Francesca Rizzo, Assunta Sellitto, Michele Santangelo, Davide De Biase, Orlando Paciello, Chiara D’Ambrosio, Stefano Amente, Corrado Garbi, Emiliano Dalla, Andrea Scaloni, Alessandro Weisz, Concetta Ambrosino, Luigi Insabato, Antonio Feliciello
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-05823-4

Internet

https://doi.org/10.1038/s42003-024-05823-4

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