Dual Targeting Ligands—Histamine H<sub>3</sub> Receptor Ligands with Monoamine Oxidase B Inhibitory Activity—In Vitro and In Vivo Evaluation

Dual Targeting Ligands—Histamine H<sub>3</sub> Receptor Ligands with Monoamine Oxidase B Inhibitory Activity—In Vitro and In Vivo Evaluation

The clinical symptoms of Parkinson’s disease (PD) appear when dopamine (DA) concentrations in the striatum drops to around 20%. Simultaneous inhibitory effects on histamine H<sub>3</sub> receptor (H<sub>3</sub>R) and MAO B can increase DA levels in the brain. A series of comp...

Full description

Bibliographic Details
Main Authors: Dorota Łażewska, Agata Siwek, Agnieszka Olejarz-Maciej, Agata Doroz-Płonka, Anna Wiktorowska-Owczarek, Marta Jóźwiak-Bębenista, David Reiner-Link, Annika Frank, Wioletta Sromek-Trzaskowska, Ewelina Honkisz-Orzechowska, Ewelina Królicka, Holger Stark, Marek Wieczorek, Waldemar Wagner, Katarzyna Kieć-Kononowicz, Anna Stasiak
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
histamine H<sub>3</sub> receptor
histamine H<sub>3</sub> receptor ligand
monoamine oxidase B (MAO B)
MAO B inhibitor
dual-target ligands
pitolisant
Online Access:https://www.mdpi.com/1999-4923/14/10/2187

Internet

https://www.mdpi.com/1999-4923/14/10/2187

Similar Items