Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models

Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models

The lack of inadequate preclinical models remains a limitation for cancer drug development and is a primary contributor to anti-cancer drug failures in clinical trials. Heterotypic multicellular spheroids are three-dimensional (3D) spherical structures generated by self-assembly from aggregates of t...

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Bibliographic Details
Main Authors: Maria L. Lotsberg, Gro V. Røsland, Austin J. Rayford, Sissel E. Dyrstad, Camilla T. Ekanger, Ning Lu, Kirstine Frantz, Linda E. B. Stuhr, Henrik J. Ditzel, Jean Paul Thiery, Lars A. Akslen, James B. Lorens, Agnete S. T. Engelsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
non-small cell lung cancer (NSCLC)
drug resistance
erlotinib-resistance
heterotypic 3D models
in vitro cell culture models
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.818437/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.818437/full

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