Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models
The lack of inadequate preclinical models remains a limitation for cancer drug development and is a primary contributor to anti-cancer drug failures in clinical trials. Heterotypic multicellular spheroids are three-dimensional (3D) spherical structures generated by self-assembly from aggregates of t...
Main Authors: | Maria L. Lotsberg, Gro V. Røsland, Austin J. Rayford, Sissel E. Dyrstad, Camilla T. Ekanger, Ning Lu, Kirstine Frantz, Linda E. B. Stuhr, Henrik J. Ditzel, Jean Paul Thiery, Lars A. Akslen, James B. Lorens, Agnete S. T. Engelsen |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-04-01
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Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.818437/full |
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