Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers

Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers

Enantiomerically enriched hydroxy-substituted b-amino esters have been synthesized through CAL-B-catalyzed enantioselective hydrolysis in organic media. Moderate to good enantiomeric excess values (ee ≥ 52%) were obtained when the CAL-B-catalyzed reactions were performed in t-BuOMe, at 60 ºC with 0....

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Bibliographic Details
Main Authors: Enikő Forró, László Schönstein, Loránd Kiss, Alberto Vega-Peñaloza, Eusebio Juaristi, Ferenc Fülöp
Format: Article
Language:English
Published: MDPI AG 2010-06-01
Series:Molecules
Subjects:
β-amino ester
stereoisomer
enzyme
hydrolysis
hydroxylation
organic solvent
enantioselective
Online Access:http://www.mdpi.com/1420-3049/15/6/3998/

Internet

http://www.mdpi.com/1420-3049/15/6/3998/

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