Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers
Enantiomerically enriched hydroxy-substituted b-amino esters have been synthesized through CAL-B-catalyzed enantioselective hydrolysis in organic media. Moderate to good enantiomeric excess values (ee ≥ 52%) were obtained when the CAL-B-catalyzed reactions were performed in t-BuOMe, at 60 ºC with 0....
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MDPI AG
2010-06-01
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Series: | Molecules |
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Online Access: | http://www.mdpi.com/1420-3049/15/6/3998/ |
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author | Enikő Forró László Schönstein Loránd Kiss Alberto Vega-Peñaloza Eusebio Juaristi Ferenc Fülöp |
author_facet | Enikő Forró László Schönstein Loránd Kiss Alberto Vega-Peñaloza Eusebio Juaristi Ferenc Fülöp |
author_sort | Enikő Forró |
collection | DOAJ |
description | Enantiomerically enriched hydroxy-substituted b-amino esters have been synthesized through CAL-B-catalyzed enantioselective hydrolysis in organic media. Moderate to good enantiomeric excess values (ee ≥ 52%) were obtained when the CAL-B-catalyzed reactions were performed in t-BuOMe, at 60 ºC with 0.5 equiv. of added H2O as nucleophile. |
first_indexed | 2024-12-22T11:27:42Z |
format | Article |
id | doaj.art-9d1aa0dd1bb64c90b9367b9d7ce544bb |
institution | Directory Open Access Journal |
issn | 1420-3049 |
language | English |
last_indexed | 2024-12-22T11:27:42Z |
publishDate | 2010-06-01 |
publisher | MDPI AG |
record_format | Article |
series | Molecules |
spelling | doaj.art-9d1aa0dd1bb64c90b9367b9d7ce544bb2022-12-21T18:27:42ZengMDPI AGMolecules1420-30492010-06-011563998401010.3390/molecules15063998Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester StereoisomersEnikő ForróLászló SchönsteinLoránd KissAlberto Vega-PeñalozaEusebio JuaristiFerenc FülöpEnantiomerically enriched hydroxy-substituted b-amino esters have been synthesized through CAL-B-catalyzed enantioselective hydrolysis in organic media. Moderate to good enantiomeric excess values (ee ≥ 52%) were obtained when the CAL-B-catalyzed reactions were performed in t-BuOMe, at 60 ºC with 0.5 equiv. of added H2O as nucleophile.http://www.mdpi.com/1420-3049/15/6/3998/β-amino esterstereoisomerenzymehydrolysishydroxylationorganic solventenantioselective |
spellingShingle | Enikő Forró László Schönstein Loránd Kiss Alberto Vega-Peñaloza Eusebio Juaristi Ferenc Fülöp Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers Molecules β-amino ester stereoisomer enzyme hydrolysis hydroxylation organic solvent enantioselective |
title | Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers |
title_full | Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers |
title_fullStr | Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers |
title_full_unstemmed | Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers |
title_short | Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers |
title_sort | direct enzymatic route for the preparation of novel enantiomerically enriched hydroxylated β amino ester stereoisomers |
topic | β-amino ester stereoisomer enzyme hydrolysis hydroxylation organic solvent enantioselective |
url | http://www.mdpi.com/1420-3049/15/6/3998/ |
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