Cnf1 Variants Endowed with the Ability to Cross the Blood–Brain Barrier: A New Potential Therapeutic Strategy for Glioblastoma

Cnf1 Variants Endowed with the Ability to Cross the Blood–Brain Barrier: A New Potential Therapeutic Strategy for Glioblastoma

Among gliomas, primary tumors originating from glial cells, glioblastoma (GBM) identified as WHO grade IV glioma, is the most common and aggressive malignant brain tumor. We have previously shown that the <i>Escherichia coli</i> protein toxin cytotoxic necrotizing factor 1 (CNF1) is rema...

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Bibliographic Details
Main Authors: Andrea Colarusso, Zaira Maroccia, Ermenegilda Parrilli, Elena Angela Pia Germinario, Andrea Fortuna, Stefano Loizzo, Laura Ricceri, Maria Luisa Tutino, Carla Fiorentini, Alessia Fabbri
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Toxins
Subjects:
glioblastoma
drug discovery
cytotoxic necrotizing factor type 1
protein purification
recombinant protein production
Online Access:https://www.mdpi.com/2072-6651/12/5/291

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https://www.mdpi.com/2072-6651/12/5/291

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