Mosaic and non-mosaic protocadherin 19 mutation leads to neuronal hyperexcitability in zebrafish

Mosaic and non-mosaic protocadherin 19 mutation leads to neuronal hyperexcitability in zebrafish

Epilepsy is one of the most common neurological disorders. The X-linked gene PCDH19 is associated with sporadic and familial epilepsy in humans, typically with early-onset clustering seizures and intellectual disability in females but not in so-called ‘carrier’ males, suggesting that mosaic PCDH19 e...

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Bibliographic Details
Main Authors: Barbara K. Robens, Xinzhu Yang, Christopher M. McGraw, Laura H. Turner, Carsten Robens, Summer Thyme, Alexander Rotenberg, Annapurna Poduri
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Neurobiology of Disease
Subjects:
PCDH19
Girls clustering epilepsy
Hyperexcitability
Zebrafish
Mosaicism
Epilepsy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122001309

Internet

http://www.sciencedirect.com/science/article/pii/S0969996122001309

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