Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury

Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury

Abstract Acute kidney injury (AKI) is a complex clinical disorder associated with poor outcomes. Targeted regulation of the degree of inflammation has been a potential strategy for AKI management. Macrophages are the main effector cells of kidney inflammation. However, macrophage heterogeneity in is...

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Bibliographic Details
Main Authors: Weijian Yao, Ying Chen, Zehua Li, Jing Ji, Abin You, Shanzhao Jin, Yuan Ma, Youlu Zhao, Jinwei Wang, Lei Qu, Hui Wang, Chengang Xiang, Suxia Wang, Gang Liu, Fan Bai, Li Yang
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Advanced Science
Subjects:
acute kidney injury
inflammation
macrophage
S100a9
single‐cell RNA‐seq
therapeutic target
Online Access:https://doi.org/10.1002/advs.202103675

Internet

https://doi.org/10.1002/advs.202103675

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