Epithelial-to-mesenchymal transition, inflammation, subsequent collagen production, and reduced proteinase expression cooperatively contribute to cyclosporin-A-induced gingival overgrowth development

Epithelial-to-mesenchymal transition, inflammation, subsequent collagen production, and reduced proteinase expression cooperatively contribute to cyclosporin-A-induced gingival overgrowth development

Drug-induced gingival overgrowth (DIGO), induced by certain immunosuppressive drugs, antihypertensive agents, and antiepileptic drugs, may contribute to the formation of deeper periodontal pockets and intractableness in periodontitis. To date, multiple factors such as enhanced matrix production, inf...

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Bibliographic Details
Main Authors: Mio Imagawa, Takanori Shinjo, Kohei Sato, Kentaro Kawakami, Tatsuro Zeze, Yuki Nishimura, Masaaki Toyoda, Shuang Chen, Naoaki Ryo, Al-kafee Ahmed, Misaki Iwashita, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Physiology
Subjects:
SPOCK-1
drug-induced gingival overgrowth
periodontitis
cyclosporin-A
epithelial-tomesenchymal transition
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1298813/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1298813/full

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